Familial Hypercholesterolaemia Panel
The hidden cholesterol gene affecting 1 in 250 people
FH is massively under-diagnosed. This panel sequences LDLR, APOB, PCSK9 and LDLRAP1 — genes that when mutated cause dangerously high LDL from birth, regardless of diet.
Istanbul, Turkey
€280
Results in 10 days
Compare with your country:
Postal saliva kit — no clinic visit required
Collect from home, post back in the pre-paid envelope. Results delivered digitally in 10 days.
What your saliva
sample reveals
LDLR full gene sequencing (1800+ variants)
APOB R3527Q & common FH mutations
PCSK9 gain-of-function variants
LDLRAP1 (autosomal recessive FH)
Cardiologist summary + statin guidance
Best for: Anyone with LDL above 5 mmol/L, xanthelasmas, or a parent who had a heart attack before 60
Explore each panel
Browse every category covered in your Familial Hypercholesterolaemia Panel — click a marker to see the action it unlocks.
PCSK9, LDLR and APOB variants that cause inherited high cholesterol regardless of diet.
PCSK9 gain-of-function
PCSK9 (chr1)
LDLR pathogenic
LDLR (chr19)
APOB R3527Q
APOB (chr2)
MTHFR (homocysteine)
MTHFR (chr1)
Turn data into action
Every finding in your report comes with a concrete next step. Here's what your results can unlock.
Get the Right Cholesterol Treatment
Most common findingTriggered by: LDLR, PCSK9, or APOB variant identified
−76%
CV mortality reduction with treatment
Click to collapse
What this result reveals:
Whether your high cholesterol is diet-driven (addressable without medication) or genetically driven by LDLR/APOB/PCSK9 mutations (which require medication regardless of how clean your diet is).
Discuss high-intensity statin therapy with your cardiologist based on your specific variant type
If statin-intolerant: PCSK9 inhibitors are highly effective for PCSK9 GOF variants
Monitor LDL-C at 3 months after starting treatment — your genetic profile predicts your expected response
Treating FH from diagnosis reduces cardiovascular mortality by 76%. Most patients normalise LDL within 8 weeks of genetically-guided therapy.
Prevent Blood Clots & DVT
Actionable immediatelyTriggered by: Factor V Leiden or Prothrombin mutation found
~0
preventable DVT risk if managed correctly
Click to see the full action protocol →
Safe Sports Participation
Athletes: essentialTriggered by: Cardiomyopathy or arrhythmia gene variant
~95%
of athlete SCA deaths are genetically explained
Click to see the full action protocol →
Every action protocol above is included in your digital report, reviewed by a specialist.
Who benefits most
Family history of heart disease
A parent or sibling had a heart attack or stroke before 60. Genetics explain whether you've inherited the same vulnerability — and what to do about it.
On cardiovascular medication
Already taking statins or antihypertensives and want to confirm your genetics justify the treatment — and whether the current drug is actually the right one for your genotype.
Unexplained palpitations or chest pain
Standard ECGs are normal, but symptoms persist. Inherited arrhythmia and structural gene variants can cause serious events in otherwise healthy people.
60 pages of actionable insight
Not a raw data dump — a structured clinical report written in plain language, reviewed by your specialist before delivery, with every finding mapped to a concrete action.
Familial Hypercholesterolaemia Panel — Genetic Report
Sample results · For illustrative purposes
1
Pathogenic variants
APOB heterozygous
FVL+
Thrombophilia risk
Actionable finding
Elevated
LDL risk
APOB driven
Low-Mod
Arrhythmia risk
RyR2 VUS monitoring
PCSK9 status
Cholesterol
LDLR status
Cholesterol
APOB status
Cholesterol
MTHFR status
Cholesterol
+ 6 more markers in your full report
Report delivered digitally in 10 days from sample receipt. Reviewed by a specialist before release.
Inside your report
60-page clinical document
Executive summary — 1-page clinician overview
Full gene-by-gene findings with reference ranges
Your variant vs. 100,000-person population norms
Ranked intervention priority list by impact
Supplement & lifestyle protocol tailored to your results
GP & specialist summary letter (formatted for referrals)
Document library access via patient portal 24/7
Report formats included
Digital PDF
Download instantly from your portal
Patient portal
Interactive results, always accessible
GP referral letter
Formatted for your local doctor
Specialist letter
Category-specific clinical summary
Included free with every test
Your patient portal is activated the moment your saliva kit is dispatched. Every result, action item, specialist message, and document — in one place, accessible 24/7 from any device.
Full report library
PDF + interactive results, always accessible
Secure specialist messaging
Direct line to your doctor, included free
Protocol reminders
Daily supplement and action item tracker
Access from any device
Web portal — no app download required
GDPR encrypted storage
Your data is private and deletable on request
Mobile-optimised
Full functionality on phone, tablet, desktop
Your action plan
1/5 done20% complete — tap any item to mark done
Cardiologist referral letter generated — download in Reports
Thrombophilia Alert Card — download for wallet
Start methylated folate (MTHFR support)
LDL-C retest in 3 months after dietary changes
Book cardiology consultation (RyR2 VUS clearance)
Portal activated instantly on kit dispatch. No app required — web-based access only.
From order to results:
4 simple steps
Everything managed through your patient portal — no clinic visits, no waiting rooms.
Saliva kit sent
Delivered to your door
Lab analysis
ISO 15189 certified lab
Specialist review
Doctor reads your results
Patient portal
Manage everything online
Patient portal: Order your kit, track shipping, view results, message your specialist, and access your complete report — all from one secure dashboard, available on any device 24/7.
Real questions from real patients
These are actual questions asked by patients about their Heart Health results — answered in full by our specialists.
Dr. Aylin Kaya
MD PhDMolecular Genetics & Epigenetics Lead
Available for consultations Mon–Fri 9am–5pm (CET)
Dr. Mehmet Yilmaz
MDClinical Genetics & Pharmacogenomics Specialist
Available for consultations Tue–Sat 8am–4pm (CET)
Have a question about your specific situation? Our specialists reply within 2 hours.
Your questions, answered
Start knowing, not guessing.
Get in touch and your coordinator will send you the complete test guide, exact pricing, and your saliva kit within 2 hours. Free, no obligation.
Complete test guide & sample report emailed immediately
Saliva kit dispatched the same working day
Secure patient portal access on day of kit dispatch
Free 15-min pre-test call to answer all your questions
Results in 10 days — reviewed by a specialist before delivery
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Familial Hypercholesterolaemia Panel
€280 · 10 days · Heart Health
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